This white paper explores evidence that improving patient engagement leads to positive outcomes for all healthcare system stakeholders. The clinical encounter is at the core of patient engagement, supporting and fostering positive health behaviors. This engagement can be amplified by patient support programs designed using the principles of behavior change, adult learning, health literacy and instructional design. Based on multi-modal instructional design, such programs can enhance engagement of patients with different learning styles, using a range of modalities – print, video, digital, mobile, or face-to-face training.